Description
Vitamin and mineral supplements.
Folic acid, vitamin B12 and vitamin B6 contribute to normal homocysteine metabolism.
In addition, vitamin B12 and vitamin B6 contribute to the normal functioning of the nervous system.
With sweetener and no added sugar.

Ingredients
Charge officer: D-mannitol, corn starch (Pearlitol Flash); vitamin B6 (pyridoxine hydrochloride); xylitol; anti-agglomerating agents: magnesium salts of fatty acids; aroma; folic acid (pteroyl-monoglutamic acid); sweetener: sucralose; vitamin B12 (cyanocobalamin).

Without gluten.
Of course without lactose.

Nutritional characteristics

Average content	for 1 tablet
Folic acid	400 mcg (200% VNR*)
Vitamin B12	50 mcg (2.000% VNR*)
Vitamin B6	10 mcg (714% VNR*)

*VNR: Nutritional Values of Adult Reference, EU Reg. 1169/2011.

Mode of use
Take 1 tablet daily, to dissolve in the mouth until complete dissolution; preferably away from meals.

Warnings
Supplements should not be understood as substitutes for a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended doses. Keep out of reach of children under three years of age. Do not take in case of hypersensitivity or allergies to one or more components.

Conservation
Store in a cool and dry place, at a temperature not exceeding 25-30°C, away from light and/or heat sources. The minimum term of preservation refers to the correctly stored product in an integral package.
Validity of whole packaging36 months.

Format
Case containing 30 orosoluble tablets of 200 mg.
Net weight 6.0 g.

Cod. 289

Any studies in support and bibliography:
Herrmann W, Herrmann M, Obeid R. Hyperhomocysteinemia: a critical review of old and new aspects. Curr Drug Metab. 2007 Jan;8(1):17-31.
- Villa P et al. Hyperhomocysteinemia and cardiovascular risk in postmenopausal women: the role of folate supplementation. Clin Chem Lab Med. 2007;45(2):130-135.
- Eldibany MM, Caprini JA. Hyperhomocysteinemia and thrombosis: an overview. Arch Pathol Lab Med. 2007 Jun;131(6):872- 84.
- Herrmann W. Meaning of hyperhomocysteinemia. Clin Lab. 2006;52(7-8):367-374.
- Selhub J. The many facets of hyperhomocysteinemia: studies from the Framingham cohorts. J Nutr. 2006 Jun;136(6 suppl):1726-1730.
- Lonn Et al. Homocysteine lowering with folic acid and b vitamins in vascular disease. N Engl J Med. 2006 Apr; 13- 354(15):1567-77.
- JF et al. Lowering homocysteine in patients with ischemic stroke to quote recurrent stroke, myocardial infarction and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA. 2004 Feb 4;291(5):565-75.
- Chambers JC et al. Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine. Circulation 2000;102:2479-83.
- Jolien de Jager et al. Long term treatment with metformin in patients type 2 diabetes and risk of vitamin B-12 deficiency: randomized placebo-controlled trial. BMJ, 2010, 340.
- Lam JR. et al. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013 Dec 11;310(22):2435-42.